59 Macrophages

Michelle To and Valentin Villatoro

Notes: Macrophages represent the mature form of monocytes when they leave the circulation and enter the tissues.1

 

Nucleus-to-Cytoplasm Ratio: N/A 2

 

Nucleoli: 1-2 2

 

Nucleus:2

Variable shapes (kidney, rounded, indented, oval)

Eccentrically located

Dark purple, coarse, clumped chromatin

 

Cytoplasm:1,2

Abundant

Irregular shaped

Many azurophilic granules

May contain ingested material and/or storage granules (hemosiderin, red blood cells, lipids, microorganisms, debris)

May contain vacuoles


References: 

1. Landis-Piwowar K. Granulocytes and Monocytes. In: Clinical laboratory hematology. 3rd ed. New Jersey: Pearson; 2015. p. 97-121.

2. Rodak BF, Carr JH. Monocyte maturation. In: Clinical hematology atlas. 5th ed. St. Louis, Missouri: Elsevier Inc.; 2017. p. 55-64.

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A Laboratory Guide to Clinical Hematology by Michelle To and Valentin Villatoro is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.

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