Both β globin chains are affected as both genes for hemoglobin S and hemoglobin C are both inherited.1,2
Complication is less severe than sickle cell disease but more severe than hemoglobin C disease. Cells are still prone to sickling under decreased oxygen tension.
Complications are similar to those seen in sickle cell anemia and vaso-occlusion can occur.
Hb S: 45%
Hb C: 45%
Hb A: None
Hb A2: 2-4%
Hb F: 1%
Solubility Tests: Positive
1. Laudicina RJ. Hemoglobinopathies: qualitative defects. In: Clinical laboratory hematology. 3rd ed. New Jersey: Pearson; 2015. p.231–50.
2. Randolph TR. Hemoglobinopathies (structural defects in hemoglobin). In: Rodak’s hematology clinical applications and principles. 5th ed. St. Louis, Missouri: Saunders; 2015. p. 426-453.