25 Pappenheimer Bodies (Siderotic Granules)

Michelle To and Valentin Villatoro

Appearance:

Inclusions are visible under both Wright/Romanowsky stains and Perls Prussian Blue stain. Pappenheimer inclusions appear as clusters of fine and irregular granules located at the periphery of the red blood cell.1-3

 

Inclusion composition:3

Iron

 

Associated Disease/Clinical States:1,2

Splenectomy

Sideroblastic Anemia

Thalassemia

Sickle Cell Disease

Hemachromatosis


References:

1. Landis-Piwowar K, Landis J, Keila P. The complete blood count and peripheral blood smear evaluation. In: Clinical laboratory hematology. 3rd ed. New Jersey:  Pearson; 2015. p. 154-77.

2. Jones KW. Evaluation of cell morphology and introduction to platelet and white blood cell morphology.  In: Clinical hematology and fundamentals of hemostasis. 5th ed. Philadelphia: F.A. Davis Company; 2009. p. 93-116.

3. Rodak BF, Carr JH. Inclusions in erythrocytes. In: Clinical hematology atlas. 5th ed. St. Louis, Missouri: Elsevier Inc.; 2017. p. 107-14.

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A Laboratory Guide to Clinical Hematology by Michelle To and Valentin Villatoro is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.

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