23 Hemoglobin SC Crystals

Michelle To and Valentin Villatoro

Appearance:

Crystals appear as a combination of sickle cells and hemoglobin C crystals. They are dark red inclusions with blunt ended projections.1 The crystals are longer than Hemoglobin C crystals, but shorter and thicker than Hemoglobin S.

 

Inclusion composition:1

Hemoglobin S and hemoglobin C

 

Associated Disease/Clinical States:1

Hemoglobin SC Disease (compound heterozygosity)


References:

1. Rodak BF, Carr JH. Variations in shape and distribution of  erythrocytes. In: Clinical hematology atlas. 5th ed. St. Louis, Missouri: Elsevier Inc.; 2017. p. 93-106.

License

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A Laboratory Guide to Clinical Hematology by Michelle To and Valentin Villatoro is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.

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